Ly49h gene
WebLink to all genes and gene products annotated to Ly49H-negative natural killer cell, mouse (excluding "regulates"). Link to all direct and indirect annotations to Ly49H-negative … Web15 apr. 2024 · Consistent with our earlier findings and regardless of the genetic background or the specific gene deletion, ... Ly49h + NK cells undergo clonal proliferation followed …
Ly49h gene
Did you know?
Web15 dec. 2008 · To identify a ligand for Ly49E, we used BWZ.36 reporter cells 18 , in which a hybrid Ly49H/E receptor together with DAP12 (referred to as H/ED12) was expressed. … Web20 mar. 2006 · Compared to C57BL/6 mice, there is a 200 kb region absent in the BALB/c cluster including a complete lack of Ly49h-related genes, which explains the increased …
Web17 mai 2002 · Moreover, a gene promoting resistance to MCMV infection, Cmv-1 , found in some strains of mice, is expressed by subsets of NK cells and encodes the activating Ly49H receptor (9–12). After exposure to m157 in vitro, Ly49H + NK cells from mice that are resistant to MCMV exhibit an increased ability to lyse target cells and to produce IFN-γ ... Web21 mar. 2024 · LY9 (Lymphocyte Antigen 9) is a Protein Coding gene. Diseases associated with LY9 include Multisystem Inflammatory Syndrome In Children and …
WebLy49H, also known as Cmv1 and Klra8, is a 28.3 kD protein. It is expressed on NK cells (but not on NKT cells) from C57BL/6 mice (but not Balb/c or DBA/2 mice). ... Gene ID 16639 View all products for this Gene ID UniProt View information about Ly49H on UniProt.org Documentation. Technical data sheet ... WebTarget Information. Ly49H is a member of the C-type lectin Ly-49 multigene family of receptors found on natural killer cells. Ly49H, like Ly49D, lacks the characteristic ITAM …
Web25 nov. 2013 · Purified NK cells were then transferred into Ly49h −/− or Il15 −/− mice by i.v. injection and monitored by congenic markers and expression of the Ly49H receptor. Single cell suspensions were generated from indicated organs and incubated with the anti-Fc receptor antibody 2.4G2 before staining with indicated mAbs (BioLegend, eBioscience ...
Web10 mar. 2024 · Ly49H has a role in antiviral activity. Signaling through the Ly49H receptor is necessary to induce transient Ly49H-mediated natural killer (NK) cell tolerance during … prince alfred park tennis centreLy49 is a family of membrane C-type lectin-like receptors expressed mainly on NK cells but also on other immune cells (some CD8+ and CD3+ T lymphocytes, intestinal epithelial lymphocytes (IELs), NKT cells, uterine NK cells (uNK) cells, macrophages or dendritic cells). Their primary role is to bind MHC-I … Vedeți mai multe Role in NK cells The function of NK cells is the killing of virally infected or cancerous cells. Therefore, they must have a precisely regulated system of self-cell recognition to prevent the … Vedeți mai multe Inhibitory receptors Inhibitory receptors play a role in the NK cell licensing and are important for recognition … Vedeți mai multe prince alfred pool loginKiller cell lectin-like receptor subfamily A (KLRA, alternative nomenclature Ly49) is a gene cluster coding proteins from family Ly49, which are membrane receptors expressed mainly on the surface of NK cells and other cells of immune system in some mammals including rodents and cattle but not humans. Mouse Klra gene cluster is located on chromosome 6 and comprises 20-30 genes and pseudogenes, e.g. Klra1 (Ly49A). Klra gene family is highly polymorphic and polygenic and vario… play to workWebWe also show a bias towards bi-allelic expression of the activating receptors based on allele-specific single-cell RT–PCR in F1 hybrid NK cells for Ly49d and Ly49H expression … prince alfred parkvilleWeb12 iun. 2006 · However, resistance was independent of Ly49H and m157, as NZW mice do not possess a Ly49H gene. Moreover, treatment with an anti-Ly49H antibody, which conferred MCMV susceptibility in C57BL/6 mice, had no effect on viral titers in NZW mice . When MCMV-resistant NZW mice were mated and backcrossed with other MCMV … play towny smpWebThe 3D10 monoclonal antibody specifically binds to mouse Lymphocyte antigen 49H (Ly-49H; also known as Klra8 or Killer cell lectin-like receptor 8). The 3D10 antibody does … playtown southport emailWeb14 mar. 2024 · In C57BL/6 mice, a subset of naive Ly49H + NK cells initiate this adaptive response after recognition of the MCMV-encoded glycoprotein m157 (refs. ... Gene ontology (GO) ... playtown southport booking