WebIndeed, we observed that a small molecule proteasome inhibitor bortezomib used for multiple myeloma treatment [32] upregulates both IRF6 and its target BLNK in ErbB2-positive breast cancer cells ... WebStudies have shown that IRF6 is low expressed in gastric cancer , and it has been recently reported that increased IRF6 expression can inhibit the proliferation, invasion and tumorigenicity of breast cancer cells and enhance the sensitivity of tumor cells to chemotherapy drugs . The role of IRF6 in colorectal cancer has not been reported as far ...
Cyproheptadine, an epigenetic modifier, exhibits anti-tumor …
WebApr 19, 2024 · Several genes, including IRF6 (interferon regulator factor 6), showed an upregulation after CPH treatment. We therein demonstrated that IRF6, a potential tumor suppressor, is epigenetically silenced by DNA methylation and histone modifications in UC. Restoration of IRF6 expression by CPH may be a novel therapeutic strategy in the … WebGenetic ablation of Ripk4 or Irf6 in mice leads to similar skin, limb, and craniofacial defects associated with epidermal hyperplasia, parakeratosis, and soft tissue fusions, as observed in humans, suggesting that the mouse models are relevant to the human disease processes [ … chemist wall hanging
IRF6 Cancer Genetics Web - CancerIndex
WebAug 23, 2013 · Non-syndromic oral clefts and risk of cancer: a systematic review Daniela Araújo Veloso Popoff, Mateus Prates Coelho, Daniella Reis Barbosa Martelli, Rajiv Saini, Ricardo Della Coletta, Hercílio Martelli-Júnior ... Lack of association between IRF6 polymorphisms and nonsyndromic oral clefts in South Indian population Venkatesh Babu ... WebSep 1, 2024 · IRF6 is initially found to be down regulated in our well established high-metastasis NPC cellular clone, and further series functional studies confirmed that IRF6 can inhibit the growth, migration, invasion, and metastasis of NPC cells. • Elevated IRF6 expression can enhance NPC chemotherapeutic sensitivity. • IRF6 gene has been observed progressively downregulated in Human papillomavirus-positive neoplastic keratinocytes derived from uterine cervical preneoplastic lesions at different levels of malignancy. For this reason, this gene is likely to be associated with tumorigenesis and may be a potential prognostic marker for uterine cervical preneoplastic lesions progression. Similarly, IRF6 has been found to be genetically and epigenetically disregulated in Vulvar cancer. flight lviv