Cdx2p-creert2
WebCDX2 is a homeobox gene that encodes a transcription protein factor that guides development of intestinal epithelial cells from the region of the duodenum to the … WebColorectal cancer (CRC) is a leading cause of cancer mortality worldwide. Mutations in the adenomatous polyposis coli (APC) gene are pivotal in colore…
Cdx2p-creert2
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WebCDX2P-CreERT2 mice express CreERT2 throughout the entire intestinal epithelium under the control of the CDX2 promoter (19, 20). AhR f/f mice carry loxP sites bordering exon 2 … WebWe tamoxifen treated 8-12 week old mice that had floxed alleles of the following: 1) both Apc alleles (giving rise to Apc truncation/inactivation); 2) both Cdx2...
WebMontgomery County, Kansas. / 37.200°N 95.733°W / 37.200; -95.733. / 37.200°N 95.733°W / 37.200; -95.733. Montgomery County (county code MG) is a county … WebDec 23, 2024 · We used the tamoxifen-regulated CDX2p-CreERT2 transgene to target both copies of the murine Apc allele (SingleMut), which leads to the development of noninvasive adenomas in the distal colon and rectum (Hinoi et al., 2007. Hinoi T. Akyol A. Theisen B.K. Ferguson D.O. Greenson J.K.
WebWe generated transgenic mice in which human CDX2 gene elements control expression of a tamoxifen-regulated Cre protein (CDX2P-CreER(T2)) to allow for inducible gene targeting in intestinal epithelium. After tamoxifen dosing of CDX2P-CreER(T2) mice, Cre activity was detected in the distal ileal, ceca … WebApr 4, 2024 · Mutation details: The transgene was designed with a 9.5 kb promoter fragment from the 5' flanking sequences of human caudal type homeo box 2 (CDX2) gene, a …
WebDownload scientific diagram Inactivation of a Ctnnb1 allele in Apc-mutant mouse colon epithelium reduces aberrant expansion of the presumptive stem cell pool expressing Msi1 or Lgr5. (A) GFP ...
WebNov 1, 2024 · Recently, colon-specific deletion of Apc has been achieved through the use of the colon-specific Cre construct, CDX2P-CreERT2 [19]. These mice carry a CDX2-NLS … top rated oled tvs 2018WebMay 1, 2024 · CDX2P-CreERT2 mice express CreERT2 throughout the entire intestinal epithelium under the control of the CDX2 promoter . AhR f/f mice carry loxP sites … top rated older motorhomesWebDataMed is a prototype biomedical data search engine. Its goal is to discover data sets across data repositories or data aggregators. In the future it will allow searching outside these boundaries. DataMed supports the NIH-endorsed FAIR principles of Findability, Accessibility, Interoperability and Reusability of datasets with current functionality … top rated olive oil brandsWebCDX2. Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. The CDX2 protein is a homeobox transcription factor expressed in the nuclei of intestinal … top rated olive leaf extractWebThe Cux2-CreERT2 "knock-in" allele has the CreER T2 fusion protein (CreERT2 fusion protein) inserted into the first coding ATG of the cut-like homeobox 2 (Cux2) locus; this was designed to both abolish Cux2 gene function (see details below) and place CreER T2 expression under the control of the Cux2 promoter/enhancer elements. Heterozygous … top rated omega 3 mini\u0027s 1000 mg one burplessWebMar 12, 2024 · Introduction. Colorectal cancer (CRC) is the third leading cause of cancer-related death in the USA and thought to arise from the acquisition of multiple mutations of genes controlling colon epithelial cell growth and differentiation that have accumulated over several decades ().Among these genes, mutation of the adenomatous polyposis coli … top rated olive oil dispenserWebColon Adenocarcinoma from tamoxifen treated CDX2P-CreERT2, Apc fl/+, Kras LSL-G12D/+, Tpr53 R270H/fl mouse 7: Organism: Mus musculus: Characteristics: strain: mixed C57BL/6 and 129 background treatment: 70 mg/kg tamoxifen, on 2 consecutive days Sex: Male: Extracted molecule: total RNA: Extraction protocol top rated omelet pan