WebJan 25, 2024 · Bone marrow adipose tissue (BMAT) plays a complex role in regulating various biological processes, including metabolism, endocrine and immune functions, hematopoeisis and skeletal homeostasis. However, our understanding of the physiological and pathological roles of BMAT remains limited. WebThe skeleton harbors an array of lineage cells that have an essential role in whole body homeostasis. Adipocytes start the colonization of marrow space early in postnatal life, expanding progressively and influencing other components of the bone marrow through paracrine signaling.
Myeloma-bone marrow adipocyte axis in tumour survival and ... - Nature
WebJan 20, 2024 · This need has led researchers to interrogate whether bone marrow adipocytes (BMAds), which increase in number and size during aging and in obesity, contribute to cancer initiation or progression within the bone marrow. Across the globe, the consensus in the field is a unified "yes". However, how to target these adipocytes or the … WebMar 9, 2024 · All mammals generate blood within their bones, and AML arises from myeloid progenitors within the bone marrow (BM) microenvironment. AML blasts exhibit high levels of spontaneous apoptosis when cultured in vitro but have a prolonged survival time in vivo, further indicating that the tissue microenvironment plays a critical role in promoting and … porthminster beach
Bone marrow adipose tissue - Wikipedia
WebApr 4, 2024 · Liu et al. reveal that glucocorticoids directly induce cellular senescence of bone-marrow adipocytes (BMAds) through a prostaglandin-PPARγ-INK positive … WebFeb 28, 2024 · The interest in bone marrow adiposity (BMA) has increased over the last decade due to its association with, and potential role, in a range of diseases … WebApr 4, 2024 · Here, we show that bone-marrow adipocyte (BMAd) lineage cells in adult mice undergo rapid cellular senescence upon glucocorticoid treatment. The senescent BMAds acquire a senescence-associated secretory phenotype, which spreads senescence in bone and bone marrow. Mechanistically, glucocorticoids increase the synthesis of … optic formal net worth 2021